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Then, the right gastrocnemius muscles were stretched repeatedly by manual ankle dorsiflexion 15 times per minute for 15min. The contralateral muscles were not stretched as a control. In the control rats ( ), the gastrocnemius was stretched as for the treatment group, but no metenolone was injected. Twenty-four hours after the procedure, the rats were sacrificed by injection of a lethal dose of sodium pentobarbital and their medial gastrocnemius muscles removed on both sides. The removed muscles were immediately preserved in liquid nitrogen and stored at 80C for RNA extraction. RNA Isolation and Analysis The tissues were homogenized with Trizol reagent (10mL/mg tissue Invitrogen, Carlsbad, CA, USA) using a hand-held homogenizer, and chloroform (0. The total RNA remained in the supernatant after extraction and after the removal of all protein and deoxyribonucleic acid by using a precipitator.


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